Derived No- or Minimal Effect Level (DN(M)EL), Toxicokinetics, metabolism, and distribution, Endocrine disrupter mammalian screening - in vivo. Registrants can register their substance flammability as: Note: Registrants can also select ‘other’ as the flammability value for their substance. Due to the number of the substances and the associated information, substance data is processed and aggregated in an automatic process.

(NTP, 1992) Aldehydes are readily oxidized to give carboxylic acids. However, substance notifications in the Brief Profile are aggregated independently of the impurities and additives. Koc at 20°C provides substance information on the substance’s Koc adsorption at a temperature 20 °C.

SMILES notations are comprised of atoms (designated by elemental symbols), bonds, parentheses (used to show branching), and numbers (used for cyclic structures). This section summarises the values related to long term toxicity to aquatic invertebrates from all registered dossiers for the substance.

Registrants can register their substance explosiveness as: Explosiveness. This section summarises the values related to toxicity to (terrestrial) arthropods from all registered dossiers for the substance. Slightly water soluble. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. If more than one result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method). There are four methods to aggregate and summarise data, depending on the available data and endpoint. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. More detailed information is available in the dossiers. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. The BPR addresses the placing on the market and use of biocidal products, which are used to protect humans, animals, materials or articles against harmful organisms, like pests or bacteria, by regulating the active substances contained in a biocidal product. Belongs to the Following Reactive Group(s), Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles. Registrant can provide information on the long and acute/short term exposure for both systemic and local effects of inhalation exposure of workers and/or general population by selecting one of the following hazard assessment conclusions: Prioritisation of display occurs based on the order above. Flash point data for this chemical are not available, however it is probably combustible. Classifications under REACH have to be supported by data (support studies). %���� The Agency thus cannot guarantee the correctness of the information displayed. Log Pow (Log Kow) provides substance information on the partition coefficient type Log Pow (Log Kow) at a temperature measured in °C. Skin irritation/corrosion provides substance information on the substance’s irritation/corrosion effect on the skin.

It may, for example, originate from the starting materials or be the result of secondary or incomplete reactions during the production process.

This section summarises the melting and freezing point values from all registered dossiers for the substance. EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram (dry weight). The CLP regulatory processes identified for the Brief Profile are: The BPR (528/2012) entered into force on 1 September 2013. Data generally displayed in milligrams per kilogram bodyweight per day. Unlike the pictograms in the ‘Classification and Labelling’ section, these icons are not determined by any legislative procedure and have the sole purpose of being informative in the context of InfoCards and Brief Profiles. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. National Oceanic and Atmospheric Administration. The source of the information is mentioned in the introductory sentence of the hazard statement. The PIC regulatory processes identified for the Brief Profile are: The ’About this substance’ section provides an overview of the volume in which this substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Values are generally displayed in milligram per kilo food. /Length 11 0 R

Half-life in soil provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C. EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. See ‘Data for workers – Inhalation exposure’, with the following additional hazard assessment conclusion in the case of short term: The registered threshold is generally displayed in milligrams per kilogram per bodyweight per day. The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The total number of non-confidential registered compositions submitted in REACH dossiers are displayed here. It is typically used a food coloring ingredient and it is found in foods like vanilla ice cream and vanilla flavored beverages. The availability of additional data beyond the five results displayed is indicated by (…) icon. This section summarises the pH values from all registered dossiers for the substance.

Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’. This section displays the values (see below) related to toxicokinetics, metabolism, and distribution from all registered dossiers for the substance. The regulation aims to protect human health and the environment by banning or severely restricting the production and use of persistent organic pollutants in the European Union. Data is generally displayed in milligrams per kilogram bodyweight per day.Prioritization by test species: See ‘Summary effect on fertility oral route’. Long-term EC10 or LC10 or NOEC for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the terrestrial plants in the test, or the no observed effect concentration for terrestrial plants.

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The substance identifiers – if available and not claimed confidential – displayed in the ’Substance identity’ section of the Brief Profile are: In addition, information on the type of substance, origin, number and type of registered compositions and other places where the substance is listed are displayed in this section. If there are additives and impurities relevant for the substance classification, these are also indicated.

Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. For this endpoint registrants do not provide study result data. EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. These numbers start with 6, 7, 8 or 9. VW denotes the form in which the substance is produced or placed on the market.

For example CLH index numbers, CN numbers, deleted CAS numbers, etc. Examples include recommended measures on fire-fighting, transport, recycling and disposal.

Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

If additional information derived from classification and labelling (C&L) notifications to ECHA under the CLP Regulation exists, this will be displayed below the information derived from harmonised classification and labelling and REACH registrations. EC10 / LC10 or NOEC for freshwater plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater plants or the no observed effect concentration for freshwater plants. Kd provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. If so, the data provided is not processed for the Brief Profile. No or insufficient data available at present, Hazard related to composition of atmosphere identified, No potential to cause toxic effects if accumulated (in higher organisms) via the food chain, bw/day (mg/kg bw/day; mg/kg bw/day; mg/kg bw/day), DMEL (Derived Minimum Effect Level) - not included for short–term effects, Insufficient data available (further information necessary), Hazard unknown but no further hazard information necessary as no exposure expected, ‘No DNEL required: short term exposure controlled by conditions for long-term’ is added, Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian), No adverse effect observed (not irritating), Adverse effect observed (irreversible damage), mg/kg bw/day (nominal/actual dose received), See ‘Study results oral: Prioritization by test species’, mg/L air (combining mg/L air, mg/L air (nominal), mg/L air (analytical), mg/m³ air, mg/m³ air (nominal), mg/m³ air (analytical)), ppm (combine ppm, ppm (nominal), ppm (analytical), mg/kg bw/day (actual dose received), mg/kg bw/day (combining mg/kg bw/day (nominal), mg/kg bw/day (actual dose received) and mg/kg bw/day), mg/cm² per day (combining mg/cm² per day, mg/cm² per day (nominal), mg/cm² per day (analytical)), No study available / no study available (further information necessary). Slowly oxidizes on exposure to air. This section summarises the Toxicological information provided from all registered dossiers for the substance. Yes, vanillin can in fact be addictive. Active substance approval – indicates if the substance is an approved biocidal active substance. 4550 Peshtera Bulgaria, Borregaard AS, Hjalmar Wessels vei 6 1701 Sarpsborg Norway, CFS Europe SpA, Via Agostino De Pretis, 6 48123 Ravenna Emilia Romagna Italy, CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland, CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(Jiangxi Brother Pharmaceutical Co.,Ltd. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). If the test material used is different from the substance being registered an indication will be provided. Registrants can choose from the following picklist endpoint conclusions/effect levels: Eye irritation provides substance information on the substance’s irritation effect on the eye. What is the Strengths of sari sari store? This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance. In this case, the preferred CAS number is displayed first.